文献荟萃
A Review of its Use as a High-Dose, Short-Course Treatment for Bacterial Infection
Abstract
Sources: Medical literature published in any language since 1980 on ‘levofloxacin’, identified using MEDLINE and EMBASE, supplemented
by AdisBase (a proprietary database of Wolters Kluwer Health | Adis). Additional references were identified from the reference lists of
published articles. Bibliographical information, including contributory unpublished data, was also requested from the company developing
the drug.
Search strategy: MEDLINE, EMBASE and AdisBase search terms were ‘levofloxacin’ and (‘community acquired pneumonia’ or ‘acute
bacterial sinusitis’ or ‘complicated urinary tract infections’ or ‘acute pyelonephritis’). Searches were last updated 26 February 2008.
Selection: Studies in patients with community-acquired pneumonia, acute bacterial sinusitis, complicated urinary tract infections or acute
pyelonephritis who received levofloxacin 750 mg for 5 days. Inclusion of studies was based mainly on the methods section of the trials.
When available, large, well controlled trials with appropriate statistical methodology were preferred. Relevant pharmacodynamic and
pharmacokinetic data are also included.
Index terms: levofloxacin, fluoroquinolones, community-acquired pneumonia, acute bacterial sinusitis, complicated urinary tract infections,
acute pyelonephritis, pharmacodynamics, pharmacokinetics, therapeutic use, tolerability.