发布日期：2005 年 9 月
英文标题：Effect of nesiritide in combination with standard therapy on serum concentrations of natriuretic peptides in patients admitted for decompensated congestive heart failure.
作者：Fitzgerald RL, Cremo R, Gardetto N, Chiu A, Clopton P, Bhalla V, Maisel AS.
出处：Am Heart J. 2005 Sep;150(3):471-7.
内容介绍：接受 rhBNP 治疗的心衰患者，BNP 水平在 12 h 内升高、随后降低；而 NT-proBNP 水平则持续降低。NT-proBNP 检测结果不受治疗药物干扰，更准确反映心衰治疗效果。
摘要展示：
OBJECTIVE:
The objective of this study is to determine the effect of nesiritide (human recombinant BNP [hBNP]) in combination with standard therapy on the concentrations of B-type natriureticpeptide (BNP) and N-terminal probrain natriuretic peptide (NT-proBNP).
BACKGROUND:
B-type natriuretic peptide is synthesized in cardiac ventricles as a prohormone (108 amino acids) and when released into peripheral circulation is cleaved into the active hormone BNP (amino acids 77-108) and an inactive amino terminal fragment NT-proBNP (amino acids 1-76).
METHODS:
Three groups of patients with acutely decompensated congestive heart failure (CHF) received nesiritide for 24, 36, or 48 hours (n = 5, 7, and 7, respectively) in addition to standardtherapy. Serial blood samples were collected. B-type natriuretic peptide and NT-proBNP were measured.
RESULTS:
To correct for positive skew, natriuretic peptide concentrations were log transformed. The mean baseline (prenesiritide), 6-, 12-, and 24-hour infusion, and 6-, 12-, and 24-hour postinfusion concentrations of BNP were 1000, 2300, 2200, 1700, 580, 640, and 740 pg/mL, respectively (n = 19). The 6- and 12-hour postinfusion concentrations of BNP were significantly lower (< 0.05) than baseline. The mean baseline, 60-, 120-, and 24-hour infusion, and 6-, 12-, and 24-hour postinfusion concentrations of NT-proBNP were 6600, 6500, 5800, 4300, 4100, 4300, and 5100 pg/mL, respectively (n = 19). From the time point 24 hours after initiation oftherapy through 12 hours postinfusion, the mean NT-proBNP concentration was significantly (< 0.05) lower than baseline.
CONCLUSION：Nesiritide, in combination with standard therapy, significantly lowered the endogenous concentrations of natriuretic peptides during infusion and after dosing was completed
