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仅含A2β-酪蛋白的牛乳与含A1和A2β-酪蛋白的牛乳对自述存在牛乳不耐受人群的消化道生理、不适症状及认知行为的影响
时间:2017-01-19 来源:丁香园

Background: Cows milk generally contains two types of β-casein, A1 and A2 types. Digestion of A1 type can yield the peptide β-casomorphin-7, which is implicated in adverse gastrointestinal effects of milk consumption, some of which resemble those in lactose intolerance. This study aimed to compare the effects of milk containing A1 β-casein with those of milk containing only A2 β-casein on inflammation, symptoms of post-dairy digestive discomfort (PD3), and cognitive processing in subjects with self-reported lactose intolerance.

 

Methods: Forty-five Han Chinese subjects participated in this double-blind, randomized, 2 × 2 crossover trial and consumed milk containing both β-casein types or milk containing only A2 β-casein. Each treatment period was 14 days with a 14-day washout period at baseline and between treatment periods. Outcomes included PD3, gastrointestinal function (measured by smart pill), Subtle Cognitive Impairment Test (SCIT), serum/fecal laboratory biomarkers, and adverse events.

 

Results: Compared with milk containing only A2 β-casein, the consumption of milk containing both β-casein types was associated with significantly greater PD3 symptoms; higher concentrations of inflammation-related biomarkers and β-casomorphin-7; longer gastrointestinal transit times and lower levels of short-chain fatty acids; and increased response time and error rate on the SCIT. Consumption of milk containing both β-casein types was associated with worsening of PD3 symptoms relative to baseline in lactose tolerant and lactose intolerant subjects. Consumption of milk containing only A2 β-casein did not aggravate PD3 symptoms relative to baseline (i.e., after washout of dairy products) in lactose tolerant and intolerant subjects.

 

Conclusions: Consumption of milk containing A1 β-casein was associated with increased gastrointestinal inflammation, worsening of PD3 symptoms, delayed transit, and decreased cognitive processing speed and accuracy. Because elimination of A1 β-casein attenuated these effects, some symptoms of lactose intolerance may stem from inflammation it triggers, and can be avoided by consuming milk containing only the A2 type of beta casein.

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学习~
发表于 2017-01-22 06:12:36
学习
发表于 2017-01-22 06:12:45
对今后饮用乳制品饮食有很好指导意义。
发表于 2017-01-22 06:25:45
学习
发表于 2017-01-22 07:52:30
还是第一次知道,一直以为是简单的乳糖不耐受。怪不得有的牛奶会拉肚子,有的不会
发表于 2017-01-23 00:17:39
也不算新闻了,很多年前就看过相关文章。印象中,羊奶和母乳也是a2蛋白的,但如果妈妈长期吃a1蛋白的牛奶,母乳中也会有a1蛋白检出。至于牛最初是产a2奶这条,是第一次听。
发表于 2017-03-06 20:18:16
有没做过母乳研究?生过小孩的都懂的。
发表于 2017-03-06 20:19:55
其实通俗点说,牛乳多为丙型B酪蛋白,利于大肠杆菌生长,而人体内有益菌多为双歧杆菌,所以间接的引起消化不适
发表于 2017-03-06 22:08:51
好的
发表于 2017-08-21 09:45:40